Abstract—Cardiac baroreflex function may be assessed from spontaneous fluctuation of systolic arterial pressure (SAP) and R-R interval. In previous studies, time-domain sequence and cross-spectral analysis had been applied to present the baroreflex response of cardiac system. Detrended fluctuation

Cardiac baroreflex function may be assessed from spontaneous fluctuation of systolic arterial pressure (SAP) and R-R interval. In previous studies, time-domain sequence and cross-spectral analysis had been applied to present the baroreflex response of cardiac system. Detrended fluctuation analysis (DFA) is also a promising algorithm to evaluate the fluctuations under various timescales. Thus, we proposed a new approach of spontaneous baroreflex sensitivity (SBR) analysis based on the technique of DFA. Meanwhile, the proposed methodology was applied to analyze the blood pressure signal during the surgery of total knee replacement (TKR) in this investigation. Analysis results show significant differences among the values of SBR under various stages of surgical operations. Keywords—Cardiac baroreflex function, systolic arterial pressure (SAP), detrended fluctuation analysis (DFA), sensitivity of baroreflex (SBR), total knee replacement (TKR).